Drug Monitoring, Ketamine, Quantitative, Urine - Ketamine is a potent dissociative anesthetic and hallucinogenic. Traditionally, used as a veterinary tranquilizer. Esketamine (Spravato®) Nasal Spray FDA-approved for Treatment Resistant Depression in Humans Depressive Symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions. Misuse and abuse occur due to the desired detachment and hallucinogenic effects associated with Ketamine.